CUSTOM ITEM: Guard Column Starter Set, Bidentate C8, complete with 5 each 4.0 mm ID x 10 mm long cartridges packed with 5 um, 300 A phase and 1 each guard column holder. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 40008‑PG4‑3 Cogent Bidentate C8 Guard Column Starter Set is a complete protection system for standard‑flow analytical HPLC columns, specifically optimized for wide‑pore (300 Å) separations involving biomolecules and larger analytes.
This starter kit includes:
(5) Bidentate C8 guard cartridges
4.0 mm ID × 10 mm length
Packed with 5 µm, 300 Å TYPE‑C™ silica hydride phase
Each cartridge is individually stored in a closeable Delrin™ case, protecting against contamination, drying, and mechanical damage prior to use.
The included holder is compatible with all Cogent TYPE‑C™ guard cartridges, allowing flexibility across multiple methods and phases.
Designed for Standard Analytical Column IDs
This starter kit is optimized for:
3.0 mm ID solvent‑saving columns
4.0 mm ID analytical columns
4.6 mm ID standard HPLC columns
This makes it ideal for conventional HPLC systems requiring reliable protection across a range of flow rates and methods.
Proper guard column selection ensures:
Minimal band broadening
Maintained separation efficiency
Consistent chromatographic performance
Why Use a 300 Å Guard Column System
The 300 Å pore size is designed for:
Peptides and proteins
Large molecular weight compounds
Complex biological and matrix‑heavy samples
Compared to 100 Å phases, 300 Å:
Improves accessibility for larger molecules
Reduces steric exclusion effects
Enhances recovery and reproducibility in biomolecule analysis
Why Use a Guard Column Starter Kit
Analytical columns are exposed to:
Particulates and debris
Strongly retained contaminants
Sample matrix buildup
Irreversible fouling
The 40008‑PG4‑3 starter kit provides a sacrificial protection layer, helping to:
Extend analytical column lifetime significantly
Maintain reliable chromatographic performance
Reduce replacement frequency and cost
Improve reproducibility across runs
Under typical laboratory conditions, the included five cartridges often provide sufficient protection for the lifetime of an analytical column, depending on sample cleanliness.
Bidentate C8 Guard Phase Advantages
Matching the guard column phase to your analytical column ensures:
Consistent selectivity and retention behavior
No disruption to method performance
Seamless analyte transfer
Compared to C18 phases, Bidentate C8:
Reduces excessive hydrophobic retention
Improves recovery of amine‑containing compounds
Provides alternative selectivity for complex separations
Supports faster equilibration cycles
Cogent TYPE‑C™ Technology Benefits
Silica Hydride Surface
Reduced silanol activity
Improved peak shape for basic and polar compounds
Lower secondary interactions
Faster Equilibration
Reduced cycle time between injections
Increased throughput in analytical workflows
Durability
Resistant to hydrolysis
Long cartridge and column life
Stable under demanding analytical conditions
Typical Applications
LC‑MS and HPLC biomolecule analysis
Peptides and protein separations
Pharmaceutical and bioanalytical workflows
Complex biological sample matrices
Methods requiring wide‑pore stationary phases
Made‑to‑Order & Pricing Information
This is a custom, made‑to‑order item.
Orders cannot be canceled once placed
Custom items are non‑returnable